Transcription factors with Perturb-seq knockdown data for PCMTD1-DT. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PCMTD1-DT upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PCMTD1-DT, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr8:51,897,928–51,898,093 | 1.2 kb | Proximal (<10kb) | 131 | |
| chr8:51,898,289–51,900,140 | 82 bp | At TSS Multiome | 870 | |
| chr8:51,904,295–51,904,474 | 5.0 kb | Proximal (<10kb) | 99 | |
| chr8:51,945,159–51,946,047 | 46.5 kb | Distal (>10kb) Multiome | 70 | |
| chr8:51,973,177–51,974,076 | 74.3 kb | Distal (>10kb) Multiome | 350 | |
| chr8:52,008,125–52,008,999 | 109.3 kb | Distal (>10kb) Multiome HiCAR | 473 | |
| chr8:52,100,809–52,101,366 | 201.8 kb | Distal (>10kb) Multiome | 219 |
Genomic view of the PCMTD1-DT locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.