The protein encoded by this gene is a component of centriolar satellites, which are electron dense granules scattered around centrosomes. Inhibition studies show that this protein is essential for the correct localization of several centrosomal proteins, and for anchoring microtubules to the centrosome. Chromosomal aberrations involving this gene are associated with papillary thyroid carcinomas and a variety of hematological malignancies, including atypical chronic myeloid leukemia and T-cell lymphoma. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2015]
Transcription factors with Perturb-seq knockdown data for PCM1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PCM1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PCM1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr8:17,748,883–17,749,493 | 173.7 kb | Distal (>10kb) Multiome | 49 | |
| chr8:17,800,593–17,801,971 | 121.7 kb | Distal (>10kb) Multiome | 778 | |
| chr8:17,912,201–17,912,908 | 10.3 kb | Distal (>10kb) Multiome | 360 | |
| chr8:17,914,907–17,915,069 | 7.8 kb | Proximal (<10kb) | 150 | |
| chr8:17,922,394–17,924,221 | 145 bp | At TSS Multiome | 992 | |
| chr8:18,083,277–18,085,104 | 161.2 kb | Distal (>10kb) Multiome | 1029 |
Genomic view of the PCM1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.