Transcription factors with Perturb-seq knockdown data for PCDH10-DT. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PCDH10-DT upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PCDH10-DT, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr4:133,145,882–133,153,168 | 2.8 kb | Proximal (<10kb) Multiome | 683 | |
| chr4:133,153,266–133,153,457 | 4.1 kb | Proximal (<10kb) | 22 | |
| chr4:133,153,571–133,153,732 | 4.4 kb | Proximal (<10kb) | 14 | |
| chr4:133,154,557–133,155,037 | 5.4 kb | Proximal (<10kb) | 78 | |
| chr4:133,156,120–133,156,492 | 7.0 kb | Proximal (<10kb) | 84 | |
| chr4:133,267,418–133,269,031 | 119.4 kb | Distal (>10kb) Multiome | 231 | |
| chr4:133,275,193–133,275,752 | 126.3 kb | Distal (>10kb) Multiome | 115 | |
| chr4:134,200,860–134,202,419 | 1052.6 kb | Distal (>10kb) Multiome HiCAR | 386 |
Genomic view of the PCDH10-DT locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.