Transcription factors with Perturb-seq knockdown data for PCCA-DT. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PCCA-DT upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PCCA-DT, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr13:99,657,854–99,658,963 | 430.5 kb | Distal (>10kb) Multiome HiCAR | 252 | |
| chr13:99,818,120–99,818,590 | 270.6 kb | Distal (>10kb) Multiome | 93 | |
| chr13:99,955,497–99,958,187 | 131.3 kb | Distal (>10kb) Multiome | 501 | |
| chr13:99,970,037–99,972,702 | 117.0 kb | Distal (>10kb) Multiome | 629 | |
| chr13:99,978,424–99,982,746 | 109.8 kb | Distal (>10kb) Multiome | 812 | |
| chr13:99,990,093–99,992,597 | 97.1 kb | Distal (>10kb) Multiome HiCAR | 378 | |
| chr13:99,996,965–99,998,156 | 91.5 kb | Distal (>10kb) Multiome HiCAR | 258 | |
| chr13:100,050,037–100,051,771 | 37.8 kb | Distal (>10kb) Multiome | 289 | |
| chr13:100,088,371–100,089,589 | 47 bp | At TSS Multiome | 925 |
Genomic view of the PCCA-DT locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.