This gene encodes a protein with multiple PDZ domains. PDZ domains mediate protein-protein interactions, and proteins with multiple PDZ domains often organize multimeric complexes at the plasma membrane. This protein localizes to tight junctions and to the apical membrane of epithelial cells. A similar protein in Drosophila is a scaffolding protein which tethers several members of a multimeric signaling complex in photoreceptors. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for PATJ. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PATJ upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PATJ, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:61,452,941–61,454,099 | 289.0 kb | Distal (>10kb) Multiome | 591 | |
| chr1:61,588,576–61,589,625 | 153.4 kb | Distal (>10kb) Multiome | 340 | |
| chr1:61,641,530–61,642,260 | 100.6 kb | Distal (>10kb) Multiome | 279 | |
| chr1:61,724,765–61,725,662 | 17.2 kb | Distal (>10kb) Multiome | 965 | |
| chr1:61,741,831–61,743,539 | 13 bp | At TSS Multiome | 689 | |
| chr1:61,743,829–61,744,474 | 1.7 kb | Proximal (<10kb) Multiome | 159 | |
| chr1:61,851,257–61,852,125 | 109.2 kb | Distal (>10kb) Multiome | 43 |
Genomic view of the PATJ locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.