Enables NAD+ poly-ADP-ribosyltransferase activity and NAD+-protein mono-ADP-ribosyltransferase activity. Involved in protein auto-ADP-ribosylation. Located in cytosol; nuclear body; and nuclear envelope. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for PARP11. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PARP11 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PARP11, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:3,705,291–3,706,096 | 167.7 kb | Distal (>10kb) Multiome | 29 | |
| chr12:3,752,872–3,753,459 | 120.2 kb | Distal (>10kb) Multiome | 419 | |
| chr12:3,872,846–3,873,625 | 23 bp | At TSS Multiome | 538 | |
| chr12:3,881,256–3,881,489 | 7.9 kb | Proximal (<10kb) | 25 | |
| chr12:3,881,646–3,881,869 | 8.3 kb | Proximal (<10kb) | 26 | |
| chr12:4,024,691–4,026,063 | 152.3 kb | Distal (>10kb) Multiome | 356 | |
| chr12:4,030,924–4,031,732 | 158.0 kb | Distal (>10kb) Multiome | 478 | |
| chr12:4,164,558–4,165,200 | 291.4 kb | Distal (>10kb) Multiome | 242 | |
| chr12:4,270,854–4,273,281 | 398.8 kb | Distal (>10kb) Multiome HiCAR | 648 | |
| chr12:4,273,341–4,274,316 | 400.4 kb | Distal (>10kb) Multiome HiCAR | 459 | |
| chr12:4,276,737–4,277,243 | 403.7 kb | Distal (>10kb) Multiome HiCAR | 453 |
Genomic view of the PARP11 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.