This gene encodes a member of the poly(A) polymerase family which catalyzes template-independent extension of the 3' end of a DNA/RNA strand. This enzyme shares 60% identity to the well characterized poly(A) polymerase II (PAPII) at the amino acid level. These two enzymes have similar organization of structural and functional domains. This enzyme is exclusively localized in the nucleus and exhibits both nonspecific and CPSF (cleavage and polyadenylation specificity factor)/AAUAAA-dependent polyadenylation activity. This gene is located on chromosome 2 in contrast to the PAPII gene, which is located on chromosome 14. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for PAPOLG. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PAPOLG upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PAPOLG, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:60,549,283–60,552,067 | 205.6 kb | Distal (>10kb) Multiome | 616 | |
| chr2:60,553,204–60,556,128 | 202.4 kb | Distal (>10kb) Multiome | 623 | |
| chr2:60,581,429–60,582,120 | 174.4 kb | Distal (>10kb) Multiome | 468 | |
| chr2:60,674,358–60,675,116 | 81.5 kb | Distal (>10kb) Multiome | 335 | |
| chr2:60,735,617–60,736,154 | 20.4 kb | Distal (>10kb) Multiome | 172 | |
| chr2:60,756,026–60,757,043 | 10 bp | At TSS Multiome | 703 | |
| chr2:60,853,117–60,853,733 | 97.1 kb | Distal (>10kb) Multiome | 48 | |
| chr2:60,880,748–60,882,118 | 125.2 kb | Distal (>10kb) Multiome | 991 | |
| chr2:61,016,845–61,018,378 | 261.2 kb | Distal (>10kb) Multiome | 1133 |
Genomic view of the PAPOLG locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.