The protein encoded by this gene belongs to the poly(A) polymerase family. It is required for the addition of adenosine residues for the creation of the 3'-poly(A) tail of mRNAs. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
Transcription factors with Perturb-seq knockdown data for PAPOLA. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PAPOLA upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PAPOLA, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr14:96,362,703–96,364,312 | 139.0 kb | Distal (>10kb) Multiome | 728 | |
| chr14:96,391,216–96,392,835 | 110.5 kb | Distal (>10kb) Multiome | 787 | |
| chr14:96,461,283–96,462,546 | 40.4 kb | Distal (>10kb) Multiome | 392 | |
| chr14:96,501,754–96,503,092 | 70 bp | At TSS Multiome | 986 | |
| chr14:96,583,910–96,584,894 | 82.0 kb | Distal (>10kb) Multiome | 345 | |
| chr14:96,592,395–96,593,217 | 90.3 kb | Distal (>10kb) Multiome | 226 | |
| chr14:96,665,756–96,666,415 | 163.7 kb | Distal (>10kb) Multiome | 41 | |
| chr14:96,693,176–96,694,444 | 191.2 kb | Distal (>10kb) Multiome | 166 | |
| chr14:96,741,173–96,742,080 | 239.2 kb | Distal (>10kb) Multiome | 370 | |
| chr14:96,797,112–96,798,108 | 294.9 kb | Distal (>10kb) Multiome | 724 |
Genomic view of the PAPOLA locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.