This gene encodes a member of the p55-like subfamily of the membrane-associated guanylate kinase (MAGUK) gene superfamily. The encoded protein participates in the polarization of differentiating cells, has been shown to regulate myelinating Schwann cells (PMID: 20237282), and is one of the components of the Crumbs complex in the retina. Mice which express lower levels of the orthologous protein have retinal degeneration and impaired vision (PMID: 22114289). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2012]
Transcription factors with Perturb-seq knockdown data for PALS1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PALS1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PALS1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr14:67,240,431–67,242,037 | 77 bp | At TSS Multiome | 924 | |
| chr14:67,359,034–67,360,833 | 118.6 kb | Distal (>10kb) Multiome | 891 | |
| chr14:67,427,006–67,427,629 | 185.9 kb | Distal (>10kb) Multiome | 288 | |
| chr14:67,514,900–67,515,814 | 273.9 kb | Distal (>10kb) Multiome | 411 | |
| chr14:67,532,784–67,533,987 | 291.9 kb | Distal (>10kb) Multiome | 684 | |
| chr14:67,541,829–67,542,290 | 300.6 kb | Distal (>10kb) Multiome | 187 |
Genomic view of the PALS1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.