The p21 activated kinases (PAK) are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. The PAK proteins are a family of serine/threonine kinases that serve as targets for the small GTP binding proteins, CDC42 and RAC1, and have been implicated in a wide range of biological activities. The protein encoded by this gene is activated by proteolytic cleavage during caspase-mediated apoptosis, and may play a role in regulating the apoptotic events in the dying cell. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for PAK2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PAK2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PAK2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:196,503,288–196,504,272 | 236.1 kb | Distal (>10kb) Multiome | 897 | |
| chr3:196,528,585–196,529,088 | 210.9 kb | Distal (>10kb) Multiome | 425 | |
| chr3:196,568,218–196,569,450 | 171.1 kb | Distal (>10kb) Multiome | 853 | |
| chr3:196,631,880–196,633,250 | 107.3 kb | Distal (>10kb) Multiome | 879 | |
| chr3:196,639,198–196,640,059 | 100.2 kb | Distal (>10kb) Multiome | 438 | |
| chr3:196,665,925–196,666,686 | 73.6 kb | Distal (>10kb) Multiome | 439 | |
| chr3:196,711,809–196,713,001 | 27.5 kb | Distal (>10kb) Multiome | 782 | |
| chr3:196,739,555–196,740,517 | 29 bp | At TSS Multiome | 736 | |
| chr3:196,867,462–196,868,618 | 128.0 kb | Distal (>10kb) Multiome | 794 | |
| chr3:196,941,814–196,943,294 | 202.7 kb | Distal (>10kb) Multiome | 1027 | |
| chr3:196,968,365–196,969,147 | 228.9 kb | Distal (>10kb) Multiome | 597 | |
| chr3:196,969,208–196,970,172 | 230.2 kb | Distal (>10kb) Multiome | 714 | |
| chr3:197,002,398–197,004,003 | 263.2 kb | Distal (>10kb) Multiome | 569 | |
| chr3:197,028,743–197,030,204 | 290.0 kb | Distal (>10kb) Multiome | 646 |
Genomic view of the PAK2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.