Predicted to enable protein kinase inhibitor activity. Involved in regulation of signal transduction by p53 class mediator and ribosomal large subunit biogenesis. Located in nucleolus. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for PAK1IP1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PAK1IP1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PAK1IP1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:10,403,471–10,405,165 | 290.6 kb | Distal (>10kb) Multiome | 843 | |
| chr6:10,411,106–10,413,568 | 282.3 kb | Distal (>10kb) Multiome | 571 | |
| chr6:10,414,758–10,415,892 | 279.7 kb | Distal (>10kb) Multiome | 461 | |
| chr6:10,416,662–10,418,068 | 277.8 kb | Distal (>10kb) Multiome | 274 | |
| chr6:10,418,929–10,420,110 | 275.5 kb | Distal (>10kb) Multiome | 403 | |
| chr6:10,487,538–10,488,562 | 207.0 kb | Distal (>10kb) Multiome | 115 | |
| chr6:10,520,974–10,521,572 | 173.7 kb | Distal (>10kb) Multiome HiCAR | 516 | |
| chr6:10,555,376–10,556,448 | 139.1 kb | Distal (>10kb) Multiome HiCAR | 264 | |
| chr6:10,582,607–10,584,703 | 111.9 kb | Distal (>10kb) Multiome | 306 | |
| chr6:10,585,189–10,585,988 | 109.3 kb | Distal (>10kb) Multiome | 131 | |
| chr6:10,659,291–10,660,431 | 35.1 kb | Distal (>10kb) Multiome | 202 | |
| chr6:10,693,057–10,693,251 | 1.7 kb | Proximal (<10kb) | 14 | |
| chr6:10,694,307–10,695,190 | 232 bp | At TSS Multiome | 980 | |
| chr6:10,722,577–10,723,508 | 28.0 kb | Distal (>10kb) Multiome | 960 | |
| chr6:10,747,079–10,748,260 | 52.7 kb | Distal (>10kb) Multiome | 1006 | |
| chr6:10,837,383–10,838,947 | 143.5 kb | Distal (>10kb) Multiome | 773 | |
| chr6:10,882,510–10,883,313 | 188.0 kb | Distal (>10kb) Multiome | 144 | |
| chr6:10,886,419–10,887,541 | 192.0 kb | Distal (>10kb) Multiome | 615 |
Genomic view of the PAK1IP1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.