Predicted to enable transmembrane transporter binding activity. Involved in endoplasmic reticulum calcium ion homeostasis; mitochondrion-endoplasmic reticulum membrane tethering; and protein localization to plasma membrane. Acts upstream of or within protein localization to phagophore assembly site. Located in endoplasmic reticulum and mitochondrion. Implicated in developmental and epileptic encephalopathy 66. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for PACS2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PACS2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PACS2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr14:105,020,271–105,022,072 | 293.5 kb | Distal (>10kb) Multiome | 813 | |
| chr14:105,045,704–105,046,235 | 268.9 kb | Distal (>10kb) Multiome | 635 | |
| chr14:105,086,627–105,087,884 | 227.8 kb | Distal (>10kb) Multiome | 590 | |
| chr14:105,090,382–105,091,009 | 224.1 kb | Distal (>10kb) Multiome | 375 | |
| chr14:105,092,908–105,094,307 | 220.8 kb | Distal (>10kb) Multiome | 495 | |
| chr14:105,167,331–105,169,463 | 145.7 kb | Distal (>10kb) Multiome | 496 | |
| chr14:105,180,714–105,181,828 | 133.5 kb | Distal (>10kb) Multiome | 392 | |
| chr14:105,248,175–105,249,386 | 66.2 kb | Distal (>10kb) Multiome | 403 | |
| chr14:105,299,994–105,301,984 | 13.5 kb | Distal (>10kb) Multiome | 829 | |
| chr14:105,313,768–105,315,755 | 153 bp | At TSS Multiome | 584 | |
| chr14:105,352,048–105,352,515 | 37.6 kb | Distal (>10kb) Multiome | 344 | |
| chr14:105,398,137–105,398,986 | 83.8 kb | Distal (>10kb) Multiome | 870 | |
| chr14:105,411,005–105,411,818 | 96.7 kb | Distal (>10kb) Multiome | 384 | |
| chr14:105,414,940–105,415,397 | 100.4 kb | Distal (>10kb) Multiome | 447 | |
| chr14:105,419,281–105,420,109 | 105.1 kb | Distal (>10kb) Multiome | 570 | |
| chr14:105,448,471–105,448,924 | 134.0 kb | Distal (>10kb) Multiome | 304 | |
| chr14:105,473,498–105,475,498 | 159.6 kb | Distal (>10kb) Multiome | 581 | |
| chr14:105,480,543–105,482,375 | 166.3 kb | Distal (>10kb) Multiome | 784 | |
| chr14:105,485,648–105,486,379 | 171.2 kb | Distal (>10kb) Multiome | 424 | |
| chr14:105,486,576–105,487,923 | 172.5 kb | Distal (>10kb) Multiome | 369 | |
| chr14:105,489,310–105,492,133 | 176.3 kb | Distal (>10kb) Multiome | 1014 | |
| chr14:105,526,110–105,527,233 | 211.8 kb | Distal (>10kb) Multiome | 270 | |
| chr14:105,528,085–105,528,965 | 213.8 kb | Distal (>10kb) Multiome | 568 |
Genomic view of the PACS2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.