Enables pH-gated chloride channel activity. Involved in chloride transport. Located in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for PACC1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PACC1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PACC1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:211,675,193–211,676,330 | 739.1 kb | Distal (>10kb) Multiome HiCAR | 936 | |
| chr1:212,034,569–212,036,407 | 379.4 kb | Distal (>10kb) Multiome HiCAR | 995 | |
| chr1:212,214,185–212,214,767 | 200.3 kb | Distal (>10kb) Multiome | 99 | |
| chr1:212,284,406–212,286,816 | 129.8 kb | Distal (>10kb) Multiome | 1049 | |
| chr1:212,309,881–212,310,794 | 104.7 kb | Distal (>10kb) Multiome | 183 | |
| chr1:212,315,914–212,316,445 | 98.8 kb | Distal (>10kb) Multiome | 140 | |
| chr1:212,413,972–212,416,004 | 38 bp | At TSS Multiome | 833 | |
| chr1:212,432,597–212,433,702 | 18.0 kb | Distal (>10kb) Multiome | 576 | |
| chr1:212,477,008–212,477,651 | 62.4 kb | Distal (>10kb) Multiome | 419 | |
| chr1:212,498,151–212,499,452 | 84.0 kb | Distal (>10kb) Multiome | 216 | |
| chr1:212,514,035–212,515,926 | 100.5 kb | Distal (>10kb) Multiome | 524 | |
| chr1:212,558,067–212,559,384 | 144.1 kb | Distal (>10kb) Multiome | 891 | |
| chr1:212,605,830–212,610,097 | 194.8 kb | Distal (>10kb) Multiome | 1097 | |
| chr1:212,629,910–212,630,849 | 215.4 kb | Distal (>10kb) Multiome | 331 | |
| chr1:212,665,118–212,665,789 | 250.6 kb | Distal (>10kb) Multiome | 678 | |
| chr1:212,698,874–212,700,500 | 284.5 kb | Distal (>10kb) Multiome | 710 |
Genomic view of the PACC1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.