This gene belongs to the polyadenylate-binding protein type-1 family of proteins. Members of this family bind to the polyA tails of mRNAs to regulate mRNA stability and translation. The mouse ortholog of this gene is required for female fertility. In human, expression of a functional protein is regulated by alternative splicing. The protein-coding splice variant for this gene is abundantly expressed in human oocytes, while a noncoding splice variant subject to nonsense-mediated decay is the predominant splice variant expressed in somatic tissues. [provided by RefSeq, Aug 2019]
Transcription factors with Perturb-seq knockdown data for PABPC1L. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PABPC1L upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PABPC1L, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr20:44,609,775–44,610,281 | 300.0 kb | Distal (>10kb) Multiome | 727 | |
| chr20:44,642,246–44,643,140 | 267.4 kb | Distal (>10kb) Multiome | 469 | |
| chr20:44,651,099–44,652,334 | 258.2 kb | Distal (>10kb) Multiome | 641 | |
| chr20:44,745,652–44,746,316 | 164.1 kb | Distal (>10kb) Multiome | 321 | |
| chr20:44,810,403–44,810,885 | 99.5 kb | Distal (>10kb) Multiome | 181 | |
| chr20:44,884,968–44,886,235 | 24.5 kb | Distal (>10kb) Multiome | 913 | |
| chr20:44,909,510–44,910,396 | 45 bp | At TSS Multiome | 810 | |
| chr20:44,911,292–44,911,995 | 1.6 kb | Proximal (<10kb) Multiome | 532 | |
| chr20:44,912,254–44,912,627 | 2.2 kb | Proximal (<10kb) | 16 | |
| chr20:44,960,068–44,960,912 | 50.5 kb | Distal (>10kb) Multiome | 1025 | |
| chr20:44,966,035–44,967,090 | 56.4 kb | Distal (>10kb) Multiome | 1001 | |
| chr20:45,098,253–45,098,840 | 188.5 kb | Distal (>10kb) Multiome | 171 |
Genomic view of the PABPC1L locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.