This gene encodes a poly(A) binding protein. The protein shuttles between the nucleus and cytoplasm and binds to the 3' poly(A) tail of eukaryotic messenger RNAs via RNA-recognition motifs. The binding of this protein to poly(A) promotes ribosome recruitment and translation initiation; it is also required for poly(A) shortening which is the first step in mRNA decay. The gene is part of a small gene family including three protein-coding genes and several pseudogenes.[provided by RefSeq, Aug 2010]
Transcription factors with Perturb-seq knockdown data for PABPC1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PABPC1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PABPC1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr8:100,559,150–100,560,136 | 162.4 kb | Distal (>10kb) Multiome HiCAR | 918 | |
| chr8:100,648,945–100,649,791 | 72.7 kb | Distal (>10kb) Multiome | 186 | |
| chr8:100,720,634–100,723,228 | 272 bp | At TSS Multiome | 1037 | |
| chr8:100,809,500–100,810,195 | 87.8 kb | Distal (>10kb) Multiome | 204 | |
| chr8:100,847,178–100,847,780 | 125.5 kb | Distal (>10kb) Multiome | 682 | |
| chr8:100,907,969–100,909,029 | 186.5 kb | Distal (>10kb) Multiome | 553 | |
| chr8:100,950,243–100,953,706 | 230.9 kb | Distal (>10kb) Multiome | 1156 |
Genomic view of the PABPC1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.