The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel with high calcium permeability. The main pharmacological distinction between the members of the purinoceptor family is the relative sensitivity to the antagonists suramin and PPADS. The product of this gene has the lowest sensitivity for these antagonists. Multiple alternatively spliced transcript variants, some protein-coding and some not protein-coding, have been found for this gene. [provided by RefSeq, Feb 2012]
Transcription factors with Perturb-seq knockdown data for P2RX4. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = P2RX4 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of P2RX4, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:121,016,022–121,016,705 | 193.6 kb | Distal (>10kb) Multiome | 674 | |
| chr12:121,026,128–121,026,637 | 183.7 kb | Distal (>10kb) Multiome | 253 | |
| chr12:121,209,800–121,210,863 | 12 bp | At TSS Multiome | 894 | |
| chr12:121,217,841–121,218,092 | 7.7 kb | Proximal (<10kb) | 74 | |
| chr12:121,230,137–121,230,781 | 20.3 kb | Distal (>10kb) Multiome | 326 | |
| chr12:121,280,329–121,281,482 | 70.7 kb | Distal (>10kb) Multiome | 112 | |
| chr12:121,295,441–121,297,879 | 86.8 kb | Distal (>10kb) Multiome | 801 | |
| chr12:121,351,979–121,352,906 | 142.4 kb | Distal (>10kb) Multiome | 928 | |
| chr12:121,399,561–121,400,983 | 189.9 kb | Distal (>10kb) Multiome | 923 | |
| chr12:121,443,293–121,443,776 | 233.3 kb | Distal (>10kb) Multiome | 302 | |
| chr12:121,466,702–121,468,225 | 257.3 kb | Distal (>10kb) Multiome | 643 |
Genomic view of the P2RX4 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.