Involved in protein N-linked glycosylation via asparagine. Part of oligosaccharyltransferase complex A and oligosaccharyltransferase complex B. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for OST4. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = OST4 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of OST4, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:26,785,402–26,786,601 | 285.7 kb | Distal (>10kb) Multiome | 996 | |
| chr2:26,846,388–26,846,855 | 225.1 kb | Distal (>10kb) Multiome | 343 | |
| chr2:26,847,436–26,849,494 | 223.7 kb | Distal (>10kb) Multiome | 447 | |
| chr2:26,961,589–26,962,066 | 109.7 kb | Distal (>10kb) Multiome | 502 | |
| chr2:26,970,294–26,971,331 | 101.1 kb | Distal (>10kb) Multiome | 572 | |
| chr2:27,032,577–27,033,271 | 38.7 kb | Distal (>10kb) Multiome | 799 | |
| chr2:27,049,564–27,052,299 | 20.9 kb | Distal (>10kb) Multiome | 1295 | |
| chr2:27,071,223–27,072,896 | 129 bp | At TSS Multiome | 864 | |
| chr2:27,081,006–27,081,641 | 9.7 kb | Proximal (<10kb) Multiome | 758 | |
| chr2:27,085,591–27,087,452 | 15.0 kb | Distal (>10kb) Multiome | 970 | |
| chr2:27,123,498–27,124,089 | 52.2 kb | Distal (>10kb) Multiome | 553 | |
| chr2:27,133,917–27,135,216 | 63.0 kb | Distal (>10kb) Multiome | 815 | |
| chr2:27,211,255–27,212,840 | 140.5 kb | Distal (>10kb) Multiome | 978 | |
| chr2:27,217,045–27,218,005 | 145.7 kb | Distal (>10kb) Multiome | 771 | |
| chr2:27,250,040–27,250,883 | 178.8 kb | Distal (>10kb) Multiome | 559 | |
| chr2:27,262,260–27,263,337 | 191.3 kb | Distal (>10kb) Multiome | 376 | |
| chr2:27,264,406–27,265,326 | 193.5 kb | Distal (>10kb) Multiome | 696 | |
| chr2:27,306,488–27,307,261 | 235.0 kb | Distal (>10kb) Multiome | 115 | |
| chr2:27,322,773–27,323,423 | 251.4 kb | Distal (>10kb) Multiome | 906 | |
| chr2:27,356,094–27,357,596 | 285.3 kb | Distal (>10kb) Multiome | 1084 | |
| chr2:27,369,685–27,371,261 | 298.8 kb | Distal (>10kb) Multiome | 1096 |
Genomic view of the OST4 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.