This gene encodes a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid receptors. Most members contain an N-terminal pleckstrin homology domain and a highly conserved C-terminal OSBP-like sterol-binding domain. Transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for OSBPL6. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = OSBPL6 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of OSBPL6, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:178,072,062–178,073,552 | 121.6 kb | Distal (>10kb) Multiome | 913 | |
| chr2:178,088,991–178,089,963 | 105.0 kb | Distal (>10kb) Multiome | 100 | |
| chr2:178,112,051–178,113,183 | 82.1 kb | Distal (>10kb) Multiome | 1042 | |
| chr2:178,193,538–178,195,689 | 122 bp | At TSS Multiome | 876 | |
| chr2:178,211,552–178,212,360 | 17.6 kb | Distal (>10kb) Multiome | 170 | |
| chr2:178,413,219–178,414,399 | 219.2 kb | Distal (>10kb) Multiome | 734 | |
| chr2:178,414,525–178,415,185 | 220.4 kb | Distal (>10kb) Multiome | 748 | |
| chr2:178,450,146–178,452,280 | 256.6 kb | Distal (>10kb) Multiome | 1097 | |
| chr2:178,477,968–178,479,684 | 284.3 kb | Distal (>10kb) Multiome | 943 | |
| chr2:178,479,849–178,481,204 | 285.9 kb | Distal (>10kb) Multiome | 786 |
Genomic view of the OSBPL6 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.