This gene encodes a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid receptors. Most members contain an N-terminal pleckstrin homology domain and a highly conserved C-terminal OSBP-like sterol-binding domain, although the encoded protein contains only the sterol-binding domain. In vitro studies have shown that the encoded protein can bind strongly to phosphatic acid and weakly to phosphatidylinositol 3-phosphate, but cannot bind to 25-hydroxycholesterol. The protein associates with the Golgi apparatus. Transcript variants encoding different isoforms have been described. [provided by RefSeq, Sep 2014]
Transcription factors with Perturb-seq knockdown data for OSBPL2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = OSBPL2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of OSBPL2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr20:62,065,357–62,067,442 | 172.5 kb | Distal (>10kb) Multiome | 841 | |
| chr20:62,121,331–62,123,419 | 116.3 kb | Distal (>10kb) Multiome | 961 | |
| chr20:62,142,789–62,144,593 | 95.0 kb | Distal (>10kb) Multiome | 841 | |
| chr20:62,182,546–62,183,326 | 55.6 kb | Distal (>10kb) Multiome | 1075 | |
| chr20:62,219,369–62,220,936 | 18.2 kb | Distal (>10kb) Multiome | 599 | |
| chr20:62,237,918–62,239,210 | 178 bp | At TSS Multiome | 794 | |
| chr20:62,301,857–62,303,576 | 63.6 kb | Distal (>10kb) Multiome | 1110 | |
| chr20:62,365,805–62,369,404 | 130.5 kb | Distal (>10kb) Multiome | 960 | |
| chr20:62,386,553–62,387,309 | 148.4 kb | Distal (>10kb) Multiome | 885 | |
| chr20:62,406,793–62,407,817 | 168.8 kb | Distal (>10kb) Multiome | 935 | |
| chr20:62,475,060–62,476,807 | 237.5 kb | Distal (>10kb) Multiome | 378 | |
| chr20:62,487,549–62,488,006 | 249.1 kb | Distal (>10kb) Multiome | 316 |
Genomic view of the OSBPL2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.