This gene encodes a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid receptors. Most members contain an N-terminal pleckstrin homology domain and a highly conserved C-terminal OSBP-like sterol-binding domain, although some members contain only the sterol-binding domain. Transcript variants derived from alternative promoter usage and/or alternative splicing exist; they encode different isoforms. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for OSBPL1A. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = OSBPL1A upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of OSBPL1A, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr18:24,014,017–24,015,501 | 383.5 kb | Distal (>10kb) Multiome | 619 | |
| chr18:24,138,655–24,139,879 | 258.8 kb | Distal (>10kb) Multiome | 483 | |
| chr18:24,176,686–24,177,648 | 220.6 kb | Distal (>10kb) Multiome | 194 | |
| chr18:24,271,142–24,272,382 | 125.9 kb | Distal (>10kb) Multiome | 485 | |
| chr18:24,368,558–24,369,702 | 28.8 kb | Distal (>10kb) Multiome | 140 | |
| chr18:24,397,168–24,398,771 | 42 bp | At TSS Multiome | 651 | |
| chr18:24,405,266–24,405,578 | 7.4 kb | Proximal (<10kb) | 6 | |
| chr18:24,426,310–24,427,225 | 28.8 kb | Distal (>10kb) Multiome | 799 |
Genomic view of the OSBPL1A locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.