This gene encodes a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid receptors. Like most members, the encoded protein contains an N-terminal pleckstrin homology domain and a highly conserved C-terminal OSBP-like sterol-binding domain. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for OSBPL11. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = OSBPL11 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of OSBPL11, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:125,357,135–125,357,657 | 238.1 kb | Distal (>10kb) Multiome | 492 | |
| chr3:125,374,544–125,375,878 | 220.2 kb | Distal (>10kb) Multiome | 864 | |
| chr3:125,519,541–125,520,583 | 75.3 kb | Distal (>10kb) Multiome | 696 | |
| chr3:125,595,065–125,596,211 | 44 bp | At TSS Multiome | 735 | |
| chr3:125,766,286–125,766,738 | 171.0 kb | Distal (>10kb) Multiome | 39 |
Genomic view of the OSBPL11 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.