The protein encoded by this gene acts as a homodimer, using ATP hydrolysis to catalyze the conversion of 5-oxo-L-proline to L-glutamate. Defects in this gene are a cause of 5-oxoprolinase deficiency (OPLAHD). [provided by RefSeq, Jun 2012]
Transcription factors with Perturb-seq knockdown data for OPLAH. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = OPLAH upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of OPLAH, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr8:143,771,202–143,772,221 | 288.9 kb | Distal (>10kb) Multiome | 405 | |
| chr8:143,814,945–143,816,493 | 244.9 kb | Distal (>10kb) Multiome | 893 | |
| chr8:143,828,724–143,829,946 | 231.3 kb | Distal (>10kb) Multiome | 933 | |
| chr8:143,840,284–143,841,979 | 219.6 kb | Distal (>10kb) Multiome | 551 | |
| chr8:143,877,814–143,879,346 | 182.1 kb | Distal (>10kb) Multiome | 444 | |
| chr8:143,941,814–143,942,929 | 118.4 kb | Distal (>10kb) Multiome | 630 | |
| chr8:143,943,562–143,944,432 | 116.7 kb | Distal (>10kb) Multiome | 587 | |
| chr8:143,951,583–143,954,394 | 106.9 kb | Distal (>10kb) Multiome | 943 | |
| chr8:143,972,817–143,973,908 | 87.1 kb | Distal (>10kb) Multiome | 436 | |
| chr8:143,976,288–143,977,568 | 83.7 kb | Distal (>10kb) Multiome | 738 | |
| chr8:143,989,521–143,991,038 | 70.7 kb | Distal (>10kb) Multiome | 596 | |
| chr8:144,049,063–144,051,761 | 10.0 kb | Distal (>10kb) Multiome | 342 | |
| chr8:144,051,869–144,052,377 | 8.3 kb | Proximal (<10kb) | 106 | |
| chr8:144,060,259–144,061,087 | 63 bp | At TSS Multiome | 727 | |
| chr8:144,078,142–144,079,235 | 18.0 kb | Distal (>10kb) Multiome | 912 | |
| chr8:144,082,187–144,083,105 | 21.9 kb | Distal (>10kb) Multiome | 763 | |
| chr8:144,094,454–144,095,491 | 34.3 kb | Distal (>10kb) Multiome | 798 | |
| chr8:144,103,485–144,105,242 | 43.6 kb | Distal (>10kb) Multiome | 1033 | |
| chr8:144,108,038–144,108,663 | 47.7 kb | Distal (>10kb) Multiome | 137 | |
| chr8:144,137,565–144,138,500 | 77.1 kb | Distal (>10kb) Multiome | 817 | |
| chr8:144,146,820–144,149,073 | 87.3 kb | Distal (>10kb) Multiome | 790 | |
| chr8:144,266,293–144,267,098 | 205.8 kb | Distal (>10kb) Multiome | 162 | |
| chr8:144,290,981–144,292,410 | 230.8 kb | Distal (>10kb) Multiome | 716 | |
| chr8:144,315,833–144,316,450 | 255.4 kb | Distal (>10kb) Multiome | 396 | |
| chr8:144,325,768–144,327,719 | 266.2 kb | Distal (>10kb) Multiome | 1016 | |
| chr8:144,331,281–144,333,847 | 271.3 kb | Distal (>10kb) Multiome | 406 | |
| chr8:144,336,102–144,339,119 | 276.2 kb | Distal (>10kb) Multiome | 922 | |
| chr8:144,353,907–144,355,227 | 293.9 kb | Distal (>10kb) Multiome | 280 | |
| chr8:144,358,142–144,359,070 | 297.9 kb | Distal (>10kb) Multiome | 719 |
Genomic view of the OPLAH locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.