Enables metalloendopeptidase activity. Involved in several processes, including HRI-mediated signaling; proteolysis; and regulation of mitochondrion organization. Located in mitochondrial inner membrane. Is active in mitochondrial intermembrane space. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for OMA1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = OMA1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of OMA1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:58,249,625–58,250,892 | 296.3 kb | Distal (>10kb) Multiome | 329 | |
| chr1:58,432,643–58,433,226 | 113.8 kb | Distal (>10kb) Multiome | 176 | |
| chr1:58,447,893–58,448,830 | 98.5 kb | Distal (>10kb) Multiome | 88 | |
| chr1:58,545,902–58,547,165 | 6 bp | At TSS Multiome | 808 | |
| chr1:58,576,513–58,577,828 | 30.5 kb | Distal (>10kb) Multiome | 406 | |
| chr1:58,699,577–58,700,464 | 153.4 kb | Distal (>10kb) Multiome | 702 | |
| chr1:58,704,094–58,705,219 | 158.1 kb | Distal (>10kb) Multiome | 154 | |
| chr1:58,782,095–58,785,778 | 237.4 kb | Distal (>10kb) Multiome | 1186 | |
| chr1:58,814,035–58,816,778 | 269.7 kb | Distal (>10kb) Multiome | 966 |
Genomic view of the OMA1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.