This gene encodes a member of the olfactomedin-like gene family which also includes genes encoding noelin, tiarin, myocilin, amassin, optimedin, photomedin, and latrophilin. The encoded protein is a secreted extracellular matrix glycoprotein with a C-terminal olfactomedin domain that facilitates protein-protein interactions, cell adhesion, and intercellular interactions. It serves as both a scaffold protein that recruits bone morphogenetic protein 1 to its substrate chordin, and as a vascular tissue remodeler with pro-angiogenic properties. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2017]
Transcription factors with Perturb-seq knockdown data for OLFML3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = OLFML3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of OLFML3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:113,758,781–113,760,075 | 219.9 kb | Distal (>10kb) Multiome | 889 | |
| chr1:113,811,244–113,812,738 | 167.1 kb | Distal (>10kb) Multiome | 978 | |
| chr1:113,904,394–113,905,850 | 74.3 kb | Distal (>10kb) Multiome | 1025 | |
| chr1:113,929,054–113,930,528 | 49.8 kb | Distal (>10kb) Multiome | 1003 | |
| chr1:113,978,866–113,979,713 | 107 bp | At TSS Multiome | 426 | |
| chr1:114,037,114–114,037,804 | 57.8 kb | Distal (>10kb) Multiome | 57 | |
| chr1:114,152,319–114,153,141 | 173.3 kb | Distal (>10kb) Multiome | 229 |
Genomic view of the OLFML3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.