Predicted to enable extracellular matrix binding activity and identical protein binding activity. Predicted to be involved in signal transduction. Predicted to act upstream of or within extracellular matrix organization. Predicted to be located in extracellular matrix and extracellular region. Predicted to be active in extracellular space. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for OLFML2A. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = OLFML2A upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of OLFML2A, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr9:124,477,322–124,478,654 | 299.2 kb | Distal (>10kb) Multiome | 223 | |
| chr9:124,482,335–124,482,814 | 294.5 kb | Distal (>10kb) Multiome | 94 | |
| chr9:124,504,291–124,505,297 | 272.1 kb | Distal (>10kb) Multiome | 187 | |
| chr9:124,769,647–124,772,472 | 5.7 kb | Proximal (<10kb) Multiome | 1006 | |
| chr9:124,774,457–124,774,680 | 2.5 kb | Proximal (<10kb) | 288 | |
| chr9:124,776,976–124,778,058 | 194 bp | At TSS Multiome | 349 | |
| chr9:124,779,329–124,780,041 | 2.5 kb | Proximal (<10kb) Multiome | 260 | |
| chr9:124,810,709–124,811,373 | 33.9 kb | Distal (>10kb) Multiome HiCAR | 209 | |
| chr9:124,839,680–124,840,329 | 62.8 kb | Distal (>10kb) Multiome HiCAR | 218 | |
| chr9:124,852,683–124,853,882 | 76.0 kb | Distal (>10kb) Multiome HiCAR | 666 | |
| chr9:124,855,555–124,856,920 | 79.1 kb | Distal (>10kb) Multiome HiCAR | 402 | |
| chr9:124,861,378–124,862,662 | 84.9 kb | Distal (>10kb) Multiome HiCAR | 947 | |
| chr9:124,868,442–124,869,814 | 92.0 kb | Distal (>10kb) Multiome HiCAR | 849 | |
| chr9:124,940,496–124,941,902 | 163.9 kb | Distal (>10kb) Multiome | 979 |
Genomic view of the OLFML2A locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.