This gene encodes a member of the GTPase protein family. The encoded protein interacts with breast cancer-associated gene 1 (BRCA1) and BRCA1-associated RING domain protein (BARD1), and is involved in centrosome regulation. Overexpression of this gene has been observed in multiple types of cancer and may be associated with poor survival. Pseudogenes of this gene have been defined on chromosomes 17 and 22. [provided by RefSeq, Jun 2016]
Transcription factors with Perturb-seq knockdown data for OLA1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = OLA1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of OLA1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:173,963,365–173,966,052 | 284.4 kb | Distal (>10kb) Multiome | 1149 | |
| chr2:174,012,758–174,013,502 | 235.5 kb | Distal (>10kb) Multiome | 292 | |
| chr2:174,023,606–174,024,194 | 224.6 kb | Distal (>10kb) Multiome | 317 | |
| chr2:174,039,708–174,040,389 | 208.5 kb | Distal (>10kb) Multiome | 694 | |
| chr2:174,053,124–174,054,219 | 195.0 kb | Distal (>10kb) Multiome | 132 | |
| chr2:174,247,891–174,249,190 | 41 bp | At TSS Multiome | 1036 | |
| chr2:174,333,695–174,335,223 | 86.3 kb | Distal (>10kb) Multiome | 488 | |
| chr2:174,335,637–174,337,967 | 88.4 kb | Distal (>10kb) Multiome | 695 | |
| chr2:174,395,360–174,396,472 | 147.2 kb | Distal (>10kb) Multiome | 847 | |
| chr2:174,486,155–174,487,807 | 238.6 kb | Distal (>10kb) Multiome | 793 |
Genomic view of the OLA1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.