The protein encoded by this gene localizes to centromeres, where it is essential for recruitment of CENP-A through the mediator Holliday junction recognition protein. Expression of this gene is upregulated in several cancers, making it a putative therapeutic target. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2015]
Transcription factors with Perturb-seq knockdown data for OIP5. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = OIP5 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of OIP5, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr15:41,115,645–41,116,753 | 216.2 kb | Distal (>10kb) Multiome | 909 | |
| chr15:41,230,581–41,231,535 | 101.5 kb | Distal (>10kb) Multiome | 1063 | |
| chr15:41,283,739–41,284,308 | 48.6 kb | Distal (>10kb) Multiome | 798 | |
| chr15:41,332,102–41,333,206 | 101 bp | At TSS Multiome | 883 | |
| chr15:41,416,690–41,417,765 | 84.5 kb | Distal (>10kb) Multiome | 734 | |
| chr15:41,493,120–41,493,918 | 161.1 kb | Distal (>10kb) Multiome | 692 | |
| chr15:41,543,905–41,544,403 | 211.6 kb | Distal (>10kb) Multiome | 687 | |
| chr15:41,558,746–41,559,337 | 226.6 kb | Distal (>10kb) Multiome | 358 | |
| chr15:41,621,149–41,622,233 | 289.2 kb | Distal (>10kb) Multiome | 998 |
Genomic view of the OIP5 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.