Predicted to enable several functions, including L-ascorbic acid binding activity; dioxygenase activity; and iron ion binding activity. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for OGFOD2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = OGFOD2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of OGFOD2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:122,751,194–122,751,767 | 223.4 kb | Distal (>10kb) Multiome | 128 | |
| chr12:122,752,332–122,753,299 | 222.0 kb | Distal (>10kb) Multiome | 978 | |
| chr12:122,774,223–122,774,865 | 200.2 kb | Distal (>10kb) Multiome | 445 | |
| chr12:122,834,656–122,836,128 | 139.3 kb | Distal (>10kb) Multiome | 514 | |
| chr12:122,895,832–122,896,391 | 78.7 kb | Distal (>10kb) Multiome | 774 | |
| chr12:122,965,963–122,966,953 | 8.2 kb | Proximal (<10kb) Multiome HiCAR | 576 | |
| chr12:122,974,115–122,975,704 | 107 bp | At TSS Multiome | 889 | |
| chr12:122,980,138–122,981,155 | 5.9 kb | Proximal (<10kb) Multiome | 817 | |
| chr12:123,049,639–123,050,104 | 75.0 kb | Distal (>10kb) Multiome | 45 | |
| chr12:123,150,285–123,151,740 | 176.3 kb | Distal (>10kb) Multiome | 487 | |
| chr12:123,232,511–123,233,923 | 258.4 kb | Distal (>10kb) Multiome | 1073 | |
| chr12:123,269,375–123,269,864 | 294.9 kb | Distal (>10kb) Multiome | 217 | |
| chr12:123,270,951–123,272,226 | 296.5 kb | Distal (>10kb) Multiome | 488 |
Genomic view of the OGFOD2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.