This gene encodes the rate-limiting enzyme of the polyamine biosynthesis pathway which catalyzes ornithine to putrescine. The activity level for the enzyme varies in response to growth-promoting stimuli and exhibits a high turnover rate in comparison to other mammalian proteins. Originally localized to both chromosomes 2 and 7, the gene encoding this enzyme has been determined to be located on 2p25, with a pseudogene located on 7q31-qter. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Dec 2013]
Transcription factors with Perturb-seq knockdown data for ODC1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ODC1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ODC1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:10,301,765–10,304,331 | 145.6 kb | Distal (>10kb) Multiome | 899 | |
| chr2:10,409,111–10,409,643 | 39.0 kb | Distal (>10kb) Multiome | 552 | |
| chr2:10,432,300–10,432,926 | 15.7 kb | Distal (>10kb) Multiome | 273 | |
| chr2:10,434,743–10,435,398 | 13.2 kb | Distal (>10kb) Multiome | 526 | |
| chr2:10,447,433–10,449,378 | 186 bp | At TSS Multiome | 1156 | |
| chr2:10,453,499–10,454,189 | 5.4 kb | Proximal (<10kb) Multiome | 50 | |
| chr2:10,477,158–10,478,678 | 29.7 kb | Distal (>10kb) Multiome | 378 | |
| chr2:10,689,600–10,690,429 | 241.7 kb | Distal (>10kb) Multiome | 876 | |
| chr2:10,721,088–10,722,120 | 273.3 kb | Distal (>10kb) Multiome | 294 |
Genomic view of the ODC1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.