Predicted to be involved in endocytosis; hematopoietic stem cell homeostasis; and positive regulation of receptor signaling pathway via JAK-STAT. Predicted to act upstream of or within response to bacterium. Located in mitochondrion. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for OCIAD2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = OCIAD2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of OCIAD2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr4:48,672,488–48,674,017 | 233.6 kb | Distal (>10kb) Multiome | 47 | |
| chr4:48,779,153–48,781,129 | 126.4 kb | Distal (>10kb) Multiome | 820 | |
| chr4:48,830,446–48,831,681 | 75.7 kb | Distal (>10kb) Multiome | 800 | |
| chr4:48,906,159–48,907,243 | 24 bp | At TSS Multiome | 490 | |
| chr4:48,914,069–48,914,976 | 7.7 kb | Proximal (<10kb) Multiome | 105 | |
| chr4:48,985,704–48,986,746 | 79.4 kb | Distal (>10kb) Multiome | 217 |
Genomic view of the OCIAD2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.