The protein encoded by this gene is a deacylase that can convert O-acetyl-ADP-ribose to ADP-ribose and acetate, O-propionyl-ADP-ribose to ADP-ribose and propionate, and O-butyryl-ADP-ribose to ADP-ribose and butyrate. The ADP-ribose product is able to inhibit these reactions through a competitive feedback loop. [provided by RefSeq, Jul 2016]
Transcription factors with Perturb-seq knockdown data for OARD1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = OARD1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of OARD1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:40,790,904–40,791,637 | 281.3 kb | Distal (>10kb) Multiome | 134 | |
| chr6:40,996,645–40,997,964 | 74.9 kb | Distal (>10kb) Multiome | 624 | |
| chr6:41,027,596–41,028,853 | 44.4 kb | Distal (>10kb) Multiome | 786 | |
| chr6:41,071,799–41,073,997 | 220 bp | At TSS Multiome | 1135 | |
| chr6:41,100,767–41,101,294 | 28.4 kb | Distal (>10kb) Multiome | 204 | |
| chr6:41,171,808–41,172,283 | 99.5 kb | Distal (>10kb) Multiome | 156 | |
| chr6:41,318,625–41,319,323 | 246.4 kb | Distal (>10kb) Multiome | 629 |
Genomic view of the OARD1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.