This gene encodes a member of the AAA (ATPases associated with diverse cellular activities) superfamily. Multiple transcript variants encoding different isoforms have been found for this gene. Two encoded proteins, described as major and minor isoforms, have been localized to distinct regions of the nucleus. The largest encoded protein (major isoform) has been localized to the nucleolus and shown to participate in ribosome biosynthesis (PMID: 15469983, 16782053), while the minor isoform has been localized to the nucleoplasmin. [provided by RefSeq, Aug 2011]
Transcription factors with Perturb-seq knockdown data for NVL. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = NVL upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of NVL, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:223,711,902–223,713,324 | 617.7 kb | Distal (>10kb) Multiome HiCAR | 708 | |
| chr1:223,992,339–223,993,214 | 337.5 kb | Distal (>10kb) Multiome HiCAR | 350 | |
| chr1:224,113,911–224,114,795 | 216.0 kb | Distal (>10kb) Multiome | 853 | |
| chr1:224,182,841–224,184,249 | 146.9 kb | Distal (>10kb) Multiome | 901 | |
| chr1:224,329,851–224,330,705 | 125 bp | At TSS Multiome | 865 | |
| chr1:224,356,549–224,357,612 | 26.8 kb | Distal (>10kb) Multiome | 791 | |
| chr1:224,434,594–224,435,312 | 104.7 kb | Distal (>10kb) Multiome | 865 | |
| chr1:224,498,011–224,499,031 | 168.5 kb | Distal (>10kb) Multiome | 326 | |
| chr1:224,502,820–224,504,228 | 173.4 kb | Distal (>10kb) Multiome | 820 | |
| chr1:224,615,699–224,617,266 | 286.0 kb | Distal (>10kb) Multiome | 511 |
Genomic view of the NVL locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.