This gene encodes a member of the nucleoporin family. The protein is localized to the nuclear rim and is an essential component of the nuclear pore complex (NPC). All molecules entering or leaving the nucleus either diffuse through or are actively transported by the NPC. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for NUP107. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = NUP107 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of NUP107, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:68,331,875–68,332,795 | 354.6 kb | Distal (>10kb) Multiome HiCAR | 616 | |
| chr12:68,538,810–68,539,554 | 147.8 kb | Distal (>10kb) Multiome | 347 | |
| chr12:68,610,127–68,611,767 | 76.2 kb | Distal (>10kb) Multiome | 846 | |
| chr12:68,686,562–68,687,457 | 69 bp | At TSS Multiome | 987 | |
| chr12:68,745,790–68,746,910 | 59.2 kb | Distal (>10kb) Multiome | 899 | |
| chr12:68,804,279–68,805,301 | 117.9 kb | Distal (>10kb) Multiome | 497 | |
| chr12:68,807,325–68,809,299 | 121.9 kb | Distal (>10kb) Multiome | 1178 | |
| chr12:68,932,729–68,933,748 | 246.3 kb | Distal (>10kb) Multiome | 457 |
Genomic view of the NUP107 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.