NUFIP1

nuclear FMR1 interacting protein 1 | NUFIP, Rsa1

This gene encodes a nuclear RNA binding protein that contains a C2H2 zinc finger motif and a nuclear localization signal. This protein is associated with the nuclear matrix in perichromatin fibrils and, in neurons, localizes to the cytoplasm in association with endoplasmic reticulum ribosomes. This protein interacts with the fragile X mental retardation protein (FMRP), the tumor suppressor protein BRCA1, upregulates RNA polymerase II transcription, and is involved in box C/D snoRNP biogenesis. A pseudogene of this gene resides on chromosome 6q12. [provided by RefSeq, Feb 2012]

Member of: DE-1 DE-1.28

Biological processes 25 terms

ATPase binding (GO:0051117)DNA binding (GO:0003677)RNA binding (GO:0003723)RNA binding (GO:0003723)RNA processing (GO:0006396)box C/D snoRNP assembly (GO:0000492)box C/D snoRNP assembly (GO:0000492)identical protein binding (GO:0042802)nuclear matrix (GO:0016363)nucleolus (GO:0005730)nucleoplasm (GO:0005654)nucleus (GO:0005634)nucleus (GO:0005634)perichromatin fibrils (GO:0005726)positive regulation of transcription by RNA polymerase II (GO:0045944)pre-snoRNP complex (GO:0070761)presynaptic active zone (GO:0048786)presynaptic active zone (GO:0048786)protein binding (GO:0005515)protein-containing complex (GO:0032991)protein-macromolecule adaptor activity (GO:0030674)protein-macromolecule adaptor activity (GO:0030674)snoRNA binding (GO:0030515)synapse (GO:0045202)transcription elongation factor complex (GO:0008023)

Expression (TPM)

TFs regulating NUFIP1 0 TFs

Transcription factors with Perturb-seq knockdown data for NUFIP1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = NUFIP1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to NUFIP1

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of NUFIP1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr13:44,764,894–44,765,379	224.2 kb	Distal (>10kb) Multiome	143
chr13:44,917,543–44,919,062	71.4 kb	Distal (>10kb) Multiome	1018
chr13:44,989,032–44,989,887	45 bp	At TSS Multiome	724
chr13:45,048,778–45,049,467	59.7 kb	Distal (>10kb) Multiome	140
chr13:45,120,138–45,120,985	131.1 kb	Distal (>10kb) Multiome	723
chr13:45,249,481–45,250,367	260.4 kb	Distal (>10kb) Multiome	120

Genome Browser

Genomic view of the NUFIP1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.