Transcription factors with Perturb-seq knockdown data for NUDT16-DT. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = NUDT16-DT upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of NUDT16-DT, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:131,361,193–131,362,506 | 19.7 kb | Distal (>10kb) Multiome | 427 | |
| chr3:131,380,871–131,382,567 | 195 bp | At TSS Multiome | 788 | |
| chr3:131,385,466–131,385,890 | 4.0 kb | Proximal (<10kb) | 11 | |
| chr3:131,386,183–131,386,578 | 4.7 kb | Proximal (<10kb) | 53 | |
| chr3:131,502,414–131,503,287 | 121.5 kb | Distal (>10kb) Multiome | 1067 | |
| chr3:131,526,553–131,527,375 | 145.5 kb | Distal (>10kb) Multiome | 204 |
Genomic view of the NUDT16-DT locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.