This gene encodes a protein with a suggested role in calcium level maintenance, eating regulation in the hypothalamus, and release of tumor necrosis factor from vascular endothelial cells. This protein binds calcium and has EF-folding domains. [provided by RefSeq, Oct 2011]
Transcription factors with Perturb-seq knockdown data for NUCB2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = NUCB2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of NUCB2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:16,986,876–16,987,479 | 289.5 kb | Distal (>10kb) Multiome | 258 | |
| chr11:17,013,111–17,015,356 | 263.2 kb | Distal (>10kb) Multiome | 708 | |
| chr11:17,077,236–17,078,393 | 199.0 kb | Distal (>10kb) Multiome | 940 | |
| chr11:17,140,897–17,141,442 | 135.6 kb | Distal (>10kb) Multiome | 103 | |
| chr11:17,207,430–17,209,576 | 68.6 kb | Distal (>10kb) Multiome | 1006 | |
| chr11:17,276,170–17,277,311 | 70 bp | At TSS Multiome | 866 | |
| chr11:17,353,357–17,353,857 | 76.9 kb | Distal (>10kb) Multiome | 768 | |
| chr11:17,388,517–17,389,964 | 112.6 kb | Distal (>10kb) Multiome | 595 | |
| chr11:17,434,869–17,435,423 | 158.5 kb | Distal (>10kb) Multiome | 84 | |
| chr11:17,476,035–17,477,288 | 200.0 kb | Distal (>10kb) Multiome | 247 | |
| chr11:17,528,160–17,528,635 | 251.6 kb | Distal (>10kb) Multiome | 181 | |
| chr11:17,543,883–17,544,680 | 267.7 kb | Distal (>10kb) Multiome | 193 | |
| chr11:17,546,803–17,547,775 | 270.5 kb | Distal (>10kb) Multiome | 187 |
Genomic view of the NUCB2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.