Predicted to enable 5'-nucleotidase activity. Predicted to be involved in negative regulation of dopamine biosynthetic process; negative regulation of oxidoreductase activity; and negative regulation of peptidyl-serine phosphorylation. Located in mitochondrion. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for NT5DC2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = NT5DC2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of NT5DC2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:52,238,767–52,239,716 | 294.6 kb | Distal (>10kb) Multiome | 763 | |
| chr3:52,245,446–52,246,450 | 287.9 kb | Distal (>10kb) Multiome | 553 | |
| chr3:52,277,664–52,279,184 | 255.2 kb | Distal (>10kb) Multiome | 844 | |
| chr3:52,287,499–52,288,336 | 245.9 kb | Distal (>10kb) Multiome | 778 | |
| chr3:52,409,430–52,411,187 | 123.6 kb | Distal (>10kb) Multiome | 813 | |
| chr3:52,444,941–52,445,411 | 88.7 kb | Distal (>10kb) Multiome | 426 | |
| chr3:52,455,213–52,455,878 | 78.3 kb | Distal (>10kb) Multiome | 630 | |
| chr3:52,518,607–52,519,389 | 14.9 kb | Distal (>10kb) Multiome | 176 | |
| chr3:52,532,907–52,533,288 | 568 bp | At TSS | 349 | |
| chr3:52,533,486–52,535,316 | 84 bp | At TSS Multiome | 648 | |
| chr3:52,536,232–52,537,450 | 2.7 kb | Proximal (<10kb) Multiome | 901 | |
| chr3:52,685,427–52,686,463 | 152.0 kb | Distal (>10kb) Multiome | 933 | |
| chr3:52,705,495–52,706,415 | 172.1 kb | Distal (>10kb) Multiome | 862 | |
| chr3:52,714,354–52,715,301 | 180.8 kb | Distal (>10kb) Multiome | 224 | |
| chr3:52,770,467–52,771,332 | 237.0 kb | Distal (>10kb) Multiome | 788 |
Genomic view of the NT5DC2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.