Involved in DNA damage response. Located in nuclear body. Part of Smc5-Smc6 complex. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for NSMCE4A. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = NSMCE4A upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of NSMCE4A, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr10:121,891,008–121,891,561 | 83.9 kb | Distal (>10kb) Multiome | 140 | |
| chr10:121,927,427–121,928,651 | 47.1 kb | Distal (>10kb) Multiome | 904 | |
| chr10:121,974,336–121,975,594 | 91 bp | At TSS Multiome | 875 | |
| chr10:122,112,641–122,114,050 | 137.7 kb | Distal (>10kb) Multiome | 855 | |
| chr10:122,162,689–122,164,583 | 188.2 kb | Distal (>10kb) Multiome | 396 |
Genomic view of the NSMCE4A locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.