Enables protein dimerization activity and ubiquitin protein ligase activity. Involved in DNA damage response. Located in nucleoplasm. Part of Smc5-Smc6 complex. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for NSMCE1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = NSMCE1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of NSMCE1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr16:26,991,912–26,993,386 | 276.0 kb | Distal (>10kb) Multiome | 93 | |
| chr16:27,080,621–27,081,394 | 187.8 kb | Distal (>10kb) Multiome | 149 | |
| chr16:27,109,686–27,110,564 | 158.8 kb | Distal (>10kb) Multiome | 416 | |
| chr16:27,203,194–27,204,605 | 65.0 kb | Distal (>10kb) Multiome | 957 | |
| chr16:27,268,647–27,268,934 | at TSS | At TSS | 781 | |
| chr16:27,313,498–27,314,279 | 45.1 kb | Distal (>10kb) Multiome | 709 | |
| chr16:27,326,759–27,327,565 | 58.5 kb | Distal (>10kb) Multiome | 524 | |
| chr16:27,549,437–27,550,571 | 281.3 kb | Distal (>10kb) Multiome | 781 |
Genomic view of the NSMCE1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.