This gene belongs to the G-protein-coupled receptor superfamily. The encoded transmembrane protein mediates the function of neuropeptide Y (NPY), a neurotransmitter, and peptide YY (PYY), a gastrointestinal hormone. The encoded receptor undergoes fast agonist-induced internalization through clathrin-coated pits and is subsequently recycled back to the cell membrane. Activation of Y1 receptors may result in mobilization of intracellular calcium and inhibition of adenylate cyclase activity. [provided by RefSeq, Aug 2013]
Transcription factors with Perturb-seq knockdown data for NPY1R. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = NPY1R upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of NPY1R, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr4:163,166,133–163,167,485 | 177.9 kb | Distal (>10kb) Multiome | 882 | |
| chr4:163,186,986–163,187,947 | 157.4 kb | Distal (>10kb) Multiome | 227 | |
| chr4:163,331,029–163,331,306 | 1.3 kb | Proximal (<10kb) | 36 | |
| chr4:163,331,418–163,333,442 | 12.0 kb | Distal (>10kb) Multiome | 499 | |
| chr4:163,343,270–163,344,825 | 6 bp | At TSS | 372 | |
| chr4:163,494,131–163,495,481 | 149.8 kb | Distal (>10kb) Multiome | 1094 | |
| chr4:164,956,712–164,957,541 | 1612.2 kb | Distal (>10kb) Multiome HiCAR | 417 |
Genomic view of the NPY1R locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.