Predicted to enable peptidase activity. Predicted to be involved in proteolysis. Located in nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for NPEPL1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = NPEPL1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of NPEPL1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr20:58,482,394–58,483,281 | 210.1 kb | Distal (>10kb) Multiome | 155 | |
| chr20:58,514,461–58,515,572 | 177.7 kb | Distal (>10kb) Multiome | 173 | |
| chr20:58,523,004–58,524,066 | 169.3 kb | Distal (>10kb) Multiome | 197 | |
| chr20:58,546,673–58,547,327 | 145.8 kb | Distal (>10kb) Multiome | 69 | |
| chr20:58,649,950–58,652,788 | 41.7 kb | Distal (>10kb) Multiome | 1208 | |
| chr20:58,669,288–58,669,967 | 23.2 kb | Distal (>10kb) Multiome | 158 | |
| chr20:58,692,413–58,693,477 | 26 bp | At TSS Multiome | 317 | |
| chr20:58,850,471–58,851,960 | 158.2 kb | Distal (>10kb) Multiome | 308 | |
| chr20:58,852,406–58,852,990 | 160.0 kb | Distal (>10kb) Multiome | 172 | |
| chr20:58,888,196–58,892,842 | 196.2 kb | Distal (>10kb) Multiome | 977 | |
| chr20:58,980,774–58,981,785 | 288.5 kb | Distal (>10kb) Multiome | 797 |
Genomic view of the NPEPL1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.