Enables palmitoleyl hydrolase activity. Involved in negative regulation of Wnt signaling pathway and protein depalmitoleylation. Acts upstream of or within bone development and regulation of bone mineralization. Predicted to be located in endoplasmic reticulum lumen and extracellular region. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for NOTUM. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = NOTUM upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of NOTUM, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:81,666,251–81,667,166 | 294.5 kb | Distal (>10kb) Multiome | 901 | |
| chr17:81,683,344–81,684,556 | 277.3 kb | Distal (>10kb) Multiome | 926 | |
| chr17:81,702,879–81,703,868 | 257.8 kb | Distal (>10kb) Multiome | 981 | |
| chr17:81,711,721–81,712,812 | 249.0 kb | Distal (>10kb) Multiome | 1056 | |
| chr17:81,832,473–81,833,976 | 127.9 kb | Distal (>10kb) Multiome | 1015 | |
| chr17:81,859,762–81,861,595 | 100.3 kb | Distal (>10kb) Multiome | 1134 | |
| chr17:81,868,421–81,868,978 | 92.6 kb | Distal (>10kb) Multiome | 577 | |
| chr17:81,869,000–81,872,289 | 89.9 kb | Distal (>10kb) Multiome | 1136 | |
| chr17:81,891,143–81,892,257 | 69.4 kb | Distal (>10kb) Multiome | 969 | |
| chr17:81,910,443–81,911,980 | 49.6 kb | Distal (>10kb) Multiome | 806 | |
| chr17:81,917,586–81,918,522 | 43.0 kb | Distal (>10kb) Multiome | 619 | |
| chr17:81,923,285–81,923,863 | 37.7 kb | Distal (>10kb) Multiome | 399 | |
| chr17:81,926,141–81,929,133 | 33.3 kb | Distal (>10kb) Multiome | 1034 | |
| chr17:81,936,855–81,937,682 | 23.8 kb | Distal (>10kb) Multiome | 854 | |
| chr17:81,959,299–81,962,169 | 1.4 kb | Proximal (<10kb) Multiome | 805 | |
| chr17:81,966,804–81,968,359 | 6.9 kb | Proximal (<10kb) Multiome | 908 | |
| chr17:81,976,595–81,978,312 | 16.5 kb | Distal (>10kb) Multiome | 1001 | |
| chr17:82,019,856–82,020,391 | 58.9 kb | Distal (>10kb) Multiome | 436 | |
| chr17:82,022,355–82,024,111 | 61.9 kb | Distal (>10kb) Multiome | 898 | |
| chr17:82,029,976–82,032,662 | 70.7 kb | Distal (>10kb) Multiome | 695 | |
| chr17:82,036,902–82,037,961 | 76.4 kb | Distal (>10kb) Multiome | 892 | |
| chr17:82,051,387–82,052,184 | 90.6 kb | Distal (>10kb) Multiome | 479 | |
| chr17:82,065,558–82,066,150 | 104.6 kb | Distal (>10kb) Multiome | 967 | |
| chr17:82,096,478–82,100,203 | 137.4 kb | Distal (>10kb) Multiome | 1085 | |
| chr17:82,103,334–82,104,356 | 142.4 kb | Distal (>10kb) Multiome | 672 | |
| chr17:82,212,405–82,213,592 | 251.7 kb | Distal (>10kb) Multiome | 911 | |
| chr17:82,228,266–82,232,536 | 267.8 kb | Distal (>10kb) Multiome | 1048 |
Genomic view of the NOTUM locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.