Enables molecular function inhibitor activity; protein heterodimerization activity; and protein-macromolecule adaptor activity. Involved in neural crest cell development; neural crest formation; and regulation of translation. Acts upstream of or within axonogenesis and regulation of synaptic plasticity. Located in fibrillar center. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for NOLC1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = NOLC1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of NOLC1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr10:101,893,696–101,895,001 | 257.9 kb | Distal (>10kb) Multiome | 142 | |
| chr10:101,960,808–101,961,342 | 191.3 kb | Distal (>10kb) Multiome | 47 | |
| chr10:102,055,474–102,056,435 | 96.3 kb | Distal (>10kb) Multiome | 955 | |
| chr10:102,064,619–102,066,067 | 87.0 kb | Distal (>10kb) Multiome | 778 | |
| chr10:102,114,483–102,115,579 | 37.3 kb | Distal (>10kb) Multiome | 546 | |
| chr10:102,119,389–102,122,276 | 31.8 kb | Distal (>10kb) Multiome | 934 | |
| chr10:102,132,334–102,133,845 | 19.5 kb | Distal (>10kb) Multiome | 968 | |
| chr10:102,151,480–102,152,882 | 144 bp | At TSS Multiome | 1009 | |
| chr10:102,169,504–102,169,976 | 17.3 kb | Distal (>10kb) Multiome | 398 | |
| chr10:102,225,881–102,226,551 | 73.8 kb | Distal (>10kb) Multiome | 652 | |
| chr10:102,229,814–102,232,116 | 77.6 kb | Distal (>10kb) Multiome | 689 | |
| chr10:102,240,581–102,242,031 | 89.2 kb | Distal (>10kb) Multiome | 504 | |
| chr10:102,244,918–102,246,010 | 93.0 kb | Distal (>10kb) Multiome | 734 | |
| chr10:102,393,940–102,396,107 | 243.3 kb | Distal (>10kb) Multiome | 912 | |
| chr10:102,399,132–102,400,002 | 247.2 kb | Distal (>10kb) Multiome HiCAR | 832 | |
| chr10:102,408,600–102,409,538 | 256.7 kb | Distal (>10kb) Multiome HiCAR | 277 | |
| chr10:102,410,213–102,410,909 | 258.4 kb | Distal (>10kb) Multiome | 148 | |
| chr10:102,418,158–102,422,381 | 267.2 kb | Distal (>10kb) Multiome | 1097 | |
| chr10:102,422,562–102,423,126 | 270.5 kb | Distal (>10kb) Multiome | 721 | |
| chr10:102,431,859–102,432,863 | 280.3 kb | Distal (>10kb) Multiome | 828 | |
| chr10:102,449,444–102,451,250 | 297.3 kb | Distal (>10kb) Multiome | 810 |
Genomic view of the NOLC1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.