NOL8 binds Ras-related GTP-binding proteins (see MIM 608267) and plays a role in cell growth (Sekiguchi et al., 2004 [PubMed 14660641]).[supplied by OMIM, Mar 2008]
Transcription factors with Perturb-seq knockdown data for NOL8. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = NOL8 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of NOL8, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr9:92,114,946–92,115,785 | 209.9 kb | Distal (>10kb) Multiome | 807 | |
| chr9:92,133,789–92,134,516 | 191.2 kb | Distal (>10kb) Multiome | 252 | |
| chr9:92,137,993–92,138,553 | 187.1 kb | Distal (>10kb) Multiome | 237 | |
| chr9:92,140,183–92,140,786 | 184.9 kb | Distal (>10kb) Multiome | 418 | |
| chr9:92,293,467–92,294,114 | 31.5 kb | Distal (>10kb) Multiome | 966 | |
| chr9:92,325,052–92,326,254 | 334 bp | At TSS Multiome | 999 |
Genomic view of the NOL8 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.