Enables RNA binding activity. Involved in maturation of SSU-rRNA and positive regulation of transcription of nucleolar large rRNA by RNA polymerase I. Located in nucleolus. Part of t-UTP complex. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for NOL11. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = NOL11 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of NOL11, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:67,376,724–67,379,389 | 340.7 kb | Distal (>10kb) Multiome HiCAR | 959 | |
| chr17:67,717,249–67,718,509 | 99 bp | At TSS Multiome | 991 | |
| chr17:67,752,011–67,752,512 | 34.5 kb | Distal (>10kb) Multiome | 77 | |
| chr17:67,779,002–67,779,504 | 61.3 kb | Distal (>10kb) Multiome | 391 | |
| chr17:67,824,729–67,826,379 | 107.5 kb | Distal (>10kb) Multiome | 892 | |
| chr17:67,974,294–67,975,317 | 256.9 kb | Distal (>10kb) Multiome | 220 | |
| chr17:67,993,084–67,994,333 | 275.8 kb | Distal (>10kb) Multiome | 896 |
Genomic view of the NOL11 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.