This gene encodes a member of the nucleotide-binding oligomerization domain (NOD)-like receptor (NLR) family of proteins. The encoded protein plays a role in innate immunity by acting as a pattern-recognition receptor (PRR) that binds bacterial peptidoglycans and initiates inflammation. This protein has also been implicated in the immune response to viral and parasitic infection. Major structural features of this protein include an N-terminal caspase recruitment domain (CARD), a centrally located nucleotide-binding domain (NBD), and 10 tandem leucine-rich repeats (LRRs) in its C terminus. The CARD is involved in apoptotic signaling, LRRs participate in protein-protein interactions, and mutations in the NBD may affect the process of oligomerization and subsequent function of the LRR domain. Mutations in this gene are associated with asthma, inflammatory bowel disease, Behcet disease and sarcoidosis in human patients. [provided by RefSeq, Aug 2017]
Transcription factors with Perturb-seq knockdown data for NOD1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = NOD1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of NOD1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:30,284,014–30,286,043 | 194.3 kb | Distal (>10kb) Multiome | 943 | |
| chr7:30,469,335–30,469,600 | 9.0 kb | Proximal (<10kb) | 204 | |
| chr7:30,472,499–30,473,444 | 5.2 kb | Proximal (<10kb) | 123 | |
| chr7:30,478,426–30,479,128 | 69 bp | At TSS Multiome | 756 | |
| chr7:30,479,551–30,480,064 | 915 bp | At TSS | 57 | |
| chr7:30,504,202–30,505,455 | 26.1 kb | Distal (>10kb) Multiome | 824 | |
| chr7:30,594,119–30,595,511 | 116.1 kb | Distal (>10kb) Multiome | 1016 | |
| chr7:30,681,420–30,682,927 | 203.8 kb | Distal (>10kb) Multiome | 319 | |
| chr7:30,699,970–30,700,584 | 221.5 kb | Distal (>10kb) Multiome | 149 | |
| chr7:30,771,029–30,771,985 | 292.8 kb | Distal (>10kb) Multiome | 536 |
Genomic view of the NOD1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.