Enables RNA binding activity. Predicted to be involved in DNA replication initiation. Predicted to act upstream of or within fat cell differentiation. Located in mitochondrion; nucleolus; and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for NOC3L. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = NOC3L upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of NOC3L, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr10:94,105,068–94,105,823 | 257.5 kb | Distal (>10kb) Multiome | 100 | |
| chr10:94,362,616–94,363,393 | 52 bp | At TSS Multiome | 1027 | |
| chr10:94,402,064–94,403,897 | 39.6 kb | Distal (>10kb) Multiome | 871 | |
| chr10:94,544,969–94,546,515 | 182.8 kb | Distal (>10kb) Multiome | 761 | |
| chr10:94,622,339–94,624,054 | 260.1 kb | Distal (>10kb) Multiome | 267 |
Genomic view of the NOC3L locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.