NME3

NME/NM23 nucleoside diphosphate kinase 3 | DR-nm23, NDPKC, NM23-H3

Enables nucleoside diphosphate kinase activity. Involved in DNA repair; mitochondrial fusion; and nucleoside triphosphate biosynthetic process. Located in mitochondrial outer membrane. [provided by Alliance of Genome Resources, Jul 2025]

Member of: DE-4 DE-4.8

Biological processes 33 terms

ADP binding (GO:0043531)CTP biosynthetic process (GO:0006241)DNA repair (GO:0006281)GDP binding (GO:0019003)GTP biosynthetic process (GO:0006183)UTP biosynthetic process (GO:0006228)apoptotic process (GO:0006915)cAMP binding (GO:0030552)ciliary basal body (GO:0036064)ciliary basal body (GO:0036064)cytoplasm (GO:0005737)cytoplasm (GO:0005737)cytoplasm (GO:0005737)cytosol (GO:0005829)dTTP biosynthetic process (GO:0006235)mitochondrial fusion (GO:0008053)mitochondrial fusion (GO:0008053)mitochondrial outer membrane (GO:0005741)mitochondrial outer membrane (GO:0005741)mitochondrial outer membrane (GO:0005741)mitochondrial outer membrane fusion (GO:1990626)mitochondrion (GO:0005739)mitochondrion (GO:0005739)mitochondrion-mitochondrion outer membrane tether activity (GO:0160204)nucleobase-containing small molecule metabolic process (GO:0055086)nucleoside diphosphate kinase activity (GO:0004550)nucleoside diphosphate kinase activity (GO:0004550)nucleoside diphosphate kinase activity (GO:0004550)nucleoside triphosphate biosynthetic process (GO:0009142)nucleoside triphosphate biosynthetic process (GO:0009142)phosphatidic acid binding (GO:0070300)protein binding (GO:0005515)protein hexamerization (GO:0034214)

Expression (TPM)

TFs regulating NME3 0 TFs

Transcription factors with Perturb-seq knockdown data for NME3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = NME3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to NME3

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of NME3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr16:1,474,566–1,475,411	296.5 kb	Distal (>10kb) Multiome	915
chr16:1,492,797–1,493,962	278.2 kb	Distal (>10kb) Multiome HiCAR	710
chr16:1,610,035–1,611,264	160.9 kb	Distal (>10kb) Multiome	745
chr16:1,611,870–1,612,834	159.3 kb	Distal (>10kb) Multiome	718
chr16:1,677,899–1,679,024	93.4 kb	Distal (>10kb) Multiome	709
chr16:1,705,380–1,706,702	65.5 kb	Distal (>10kb) Multiome	933
chr16:1,763,511–1,764,353	7.5 kb	Proximal (<10kb) Multiome	261
chr16:1,770,847–1,771,973	22 bp	At TSS Multiome	485
chr16:1,772,565–1,774,049	1.8 kb	Proximal (<10kb) Multiome	956
chr16:1,781,749–1,783,420	11.2 kb	Distal (>10kb) Multiome	761
chr16:1,826,102–1,827,535	55.3 kb	Distal (>10kb) Multiome	1006
chr16:1,918,171–1,918,773	146.9 kb	Distal (>10kb) Multiome	129
chr16:1,929,283–1,930,271	158.3 kb	Distal (>10kb) Multiome	780
chr16:1,942,671–1,943,761	171.8 kb	Distal (>10kb) Multiome	750
chr16:1,958,923–1,960,140	187.9 kb	Distal (>10kb) Multiome	826
chr16:1,964,300–1,965,434	193.3 kb	Distal (>10kb) Multiome	933
chr16:1,971,481–1,972,435	200.4 kb	Distal (>10kb) Multiome	1010
chr16:1,979,111–1,980,324	207.9 kb	Distal (>10kb) Multiome	296
chr16:1,983,450–1,984,851	212.4 kb	Distal (>10kb) Multiome	917
chr16:1,989,307–1,993,568	220.8 kb	Distal (>10kb) Multiome	706
chr16:2,003,882–2,004,348	232.5 kb	Distal (>10kb) Multiome	619
chr16:2,009,742–2,010,504	238.3 kb	Distal (>10kb) Multiome	752
chr16:2,022,700–2,023,923	251.7 kb	Distal (>10kb) Multiome	682
chr16:2,026,629–2,027,149	255.3 kb	Distal (>10kb) Multiome	249
chr16:2,047,366–2,048,252	276.3 kb	Distal (>10kb) Multiome	875

Genome Browser

Genomic view of the NME3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.