Nucleoside diphosphate kinase (NDK) exists as a hexamer composed of 'A' (encoded by NME1) and 'B' (encoded by this gene) isoforms. Multiple alternatively spliced transcript variants have been found for this gene. Read-through transcription from the neighboring upstream gene (NME1) generates naturally-occurring transcripts (NME1-NME2) that encode a fusion protein comprised of sequence sharing identity with each individual gene product. [provided by RefSeq, Nov 2010]
Transcription factors with Perturb-seq knockdown data for NME2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = NME2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of NME2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:50,865,239–50,868,097 | 300.0 kb | Distal (>10kb) Multiome | 1256 | |
| chr17:50,905,047–50,905,768 | 260.8 kb | Distal (>10kb) Multiome | 556 | |
| chr17:50,931,004–50,931,866 | 235.2 kb | Distal (>10kb) Multiome | 780 | |
| chr17:50,944,102–50,945,190 | 221.8 kb | Distal (>10kb) Multiome | 985 | |
| chr17:50,950,043–50,950,638 | 215.9 kb | Distal (>10kb) Multiome | 713 | |
| chr17:51,119,858–51,121,548 | 45.5 kb | Distal (>10kb) Multiome | 961 | |
| chr17:51,153,226–51,154,064 | 12.9 kb | Distal (>10kb) Multiome | 1231 | |
| chr17:51,165,369–51,167,398 | 38 bp | At TSS Multiome | 1044 | |
| chr17:51,259,114–51,261,477 | 93.9 kb | Distal (>10kb) Multiome | 1119 |
Genomic view of the NME2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.