This gene (NME1) was identified because of its reduced mRNA transcript levels in highly metastatic cells. Nucleoside diphosphate kinase (NDK) exists as a hexamer composed of 'A' (encoded by this gene) and 'B' (encoded by NME2) isoforms. Mutations in this gene have been identified in aggressive neuroblastomas. Two transcript variants encoding different isoforms have been found for this gene. Co-transcription of this gene and the neighboring downstream gene (NME2) generates naturally-occurring transcripts (NME1-NME2), which encodes a fusion protein comprised of sequence sharing identity with each individual gene product. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for NME1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = NME1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of NME1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:50,865,239–50,868,097 | 287.1 kb | Distal (>10kb) Multiome | 1256 | |
| chr17:50,905,047–50,905,768 | 248.0 kb | Distal (>10kb) Multiome | 556 | |
| chr17:50,931,004–50,931,866 | 222.3 kb | Distal (>10kb) Multiome | 780 | |
| chr17:50,944,102–50,945,190 | 208.9 kb | Distal (>10kb) Multiome | 985 | |
| chr17:50,950,043–50,950,638 | 203.0 kb | Distal (>10kb) Multiome | 713 | |
| chr17:51,119,858–51,121,548 | 32.6 kb | Distal (>10kb) Multiome | 961 | |
| chr17:51,153,226–51,154,064 | 76 bp | At TSS Multiome | 1231 | |
| chr17:51,165,369–51,167,398 | 12.8 kb | Distal (>10kb) Multiome | 1044 | |
| chr17:51,259,114–51,261,477 | 106.7 kb | Distal (>10kb) Multiome | 1119 |
Genomic view of the NME1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.